Learning Center
Identifying and Managing Infusion-Related Hypersensitivity Reactions (HSRs) to Antineoplastics [virtual]
Chemotherapy-induced hypersensitivity reactions (HSRs) represent the third leading cause of fatal drug-induced anaphylaxis in the United States. An estimated 23 million adult patient visits occur annually for cancer treatment in the United States, and approximately 19 million of those visits (84%) are delivered in ambulatory settings. By 2050, the number of cancer cases is expected to double, thereby increasing the use of antineoplastic drugs. Anaphylaxis is life-threatening and early recognition and intervention are key. Delayed biphasic anaphylactic reactions can occur after initial exposure in as many as 20% of patients. This session will provide an overview of chemotherapy-induced HSRs and present the latest evidence on prevention and treatment.
Learning Objectives: At the conclusion of this session, participants will be able to:
- Describe the pathophysiology of infusion-related HSRs to chemotherapy and immunotherapy agents.
- Explain strategies for prevention of infusion-related HSRs.
- Discuss evidence-based guidelines for the management of Infusion-related HSRs.
Contact Hours: 1
CRNI® RUs: 2
Mikaela Olsen, DNP, APRN-CNS, AOCNS®, FAAN
Dr. Mikaela Olsen is the clinical program director for oncology at The Johns Hopkins Hospital and The Johns Hopkins Health System, where she works closely with oncology nurse leaders, oncology physician leaders, and clinical staff to ensure best practice and streamlined coordination of care and collaborates with oncology service line leadership to ensure that oncology core competencies and standards of care are consistent and harmonized throughout The Johns Hopkins cancer service line. Dr. Olsen serves as adjunct faculty for The Johns Hopkins School of Nursing and as a faculty associate at the University of Maryland School of Nursing. She is the manager of the peripherally inserted central line catheter (PICC) team for the department of oncology, the chair of The Johns Hopkins Hospital and Johns Hopkins Health System Venous Access Device Committees, and cochair of the CLABSI Reduction Committee. She is currently the lead editor for the 2nd edition of the Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (2019) and the 4th edition of the Safe Handling of Hazardous Drugs. Dr. Olsen has published and extensively presented on the topic of VAD evidence-based practice and CLABSI reduction and safe handling of hazardous drugs. As an instructor and consultant, she has traveled to countries including Singapore, UAE, China, Bulgaria, and Japan to improve nursing education related to cancer and cancer treatment and to increase awareness of HD exposure risks and safe handling and prevention of CLABSIs.